Insights
How Nobel-awarded MOF material science and LabInCube’s patented InCube™ Technology shaped PLLACUBE®, a next-generation professional skinbooster.
From Nobel Prize–Winning Chemistry to Professional Skinboosters In October 2025, the Nobel Prize in Chemistry was awarded to Professor Omar M. Yaghi and colleagues for the development of Metal–Organic Frameworks (MOFs) – an entirely new class of highly porous molecular architectures capable of selectively capturing and protecting target molecules. While MOFs were originally developed for advanced applications such as gas storage, carbon capture, and environmental materials, this same molecular design concept has now entered the field of professional skincare – including the material-science platform behind PLLACUBE®. Dr. Kyungmin Choi & the Yaghi Lab Connection PLLACUBE® is developed by LabInCube Co., Ltd., a Korean biomaterial R&D company founded by Professor Kyungmin Choi of Sookmyung Women’s University’s Department of Chemical and Biomolecular Engineering. Early in his career, Dr. Choi conducted postdoctoral research in the MOF laboratory of Professor Omar M. Yaghi at the University of California, Berkeley. This world-leading MOF research environment — later recognized by the 2025 Nobel Prize in Chemistry — provided the scientific foundation for Dr. Choi’s work in MOF-inspired material science. According to Sookmyung Women’s University’s tech holding company, this research connection evolved into a formal technology advisory agreement between LabInCube and Professor Yaghi. Leveraging this collaboration, LabInCube successfully adapted MOF-related concepts into consumer and aesthetic applications. World’s First Commercialization of MOF Concepts into Daily-Life Products For many years, MOF technology was mainly used in fields such as petrochemicals, semiconductors, and environmental engineering. A university report notes that in 2024 LabInCube became the first company worldwide to commercialize MOF-based material science in everyday products – bringing high-level chemistry into real-world applications. This milestone represents a shift: MOF-inspired architectures are no longer exclusive to academic or industrial settings but are now being translated into solutions for air-care, beauty, and health products. One major outcome is the proprietary InCube™ Protection Technology used in PLLACUBE®. InCube™ Protection Technology Inside PLLACUBE® PLLACUBE® is a next-generation skinbooster combining Poly-L-Lactic Acid (PLLA), PDRN, Vitamin C, Glutathione, Houttuynia Cordata Extract, and Hyaluronic Acid. Behind this formula is a patented material-science system known as InCube™ Protection Technology. Inspired by MOF-like structural principles, InCube™ creates a controlled micro-environment that helps: Encapsulate and shield vulnerable cosmetic ingredients such as Vitamin C and Glutathione from premature oxidation. Support ingredient integrity and freshness throughout production, storage, and application. Provide a more consistent user experience by maintaining stability of key actives in every vial. This technology is protected by international patent (Patent No. 10-2488551) and represents a new approach to cosmetic stabilization that integrates advanced material science with professional skincare needs. What This Means for Clinics in Canada & North America For medical spas and aesthetic clinics, PLLACUBE® represents more than a multi-ingredient skinbooster — it embodies the translation of Nobel Prize–winning material science into a practical, clinic-ready product. A formulation developed by a team with direct experience in a Nobel-recognized MOF research environment. A patented stabilization platform designed to protect sensitive cosmetic ingredients. A 5th-generation skinbooster concept that brings scientific innovation into real-world treatment settings. Full Scientific Document (PDF) ReferencesJoongAng News / Sookmyung Women’s University Tech Holdings – feature on LabInCube Co., Ltd. and MOF commercialization (2024).NobelPrize.org – 2025 Nobel Prize in Chemistry: Metal–Organic Frameworks (MOFs) – Omar M. Yaghi and co-laureates.LabInCube Scientific Document (PDF): MOF → InCube™ → PLLACUBE® Technical Explanation
Learn more
PLLACUBE Clinical Before & After Results – Proven Improvements in Pores, Texture, Hydration & Skin Tone
Clinical Before & After Results with PLLACUBE Documented improvements in skin pores, texture, hydration, and brightness after 3 weeks of treatment. All images captured under standardized, controlled lighting as part of a GCP-compliant clinical study. Skin Pores (Volume) Measured by Antera 3D – Average pore volume reduced after 3 weeks of PLLACUBE application, improving overall skin smoothness. Before After 3 Weeks Skin Texture (Ra, μm) Measured by Antera 3D – Significant reduction in surface roughness (Ra), creating a smoother, refined skin texture. Before After 3 Weeks Epidermal Hydration Measured by Epsilon E100 – Visible increase in skin moisture levels, contributing to plumpness and a healthy glow. Before After 3 Weeks Skin Tone / Brightness (L*) Measured by Mark-Vu Colorimeter – Improved L* value indicates brighter, more even skin tone after PLLACUBE use. Before After 3 Weeks
Learn more
PLLACUBE: 0.00 Irritation Index & Clinically Proven Skin Improvements in 3 Weeks
0.00 Irritation Index — Rated ‘Excellent’ Dermatologist‑evaluated 24‑hour primary irritation test on clinically confirmed sensitive skin. Test Item Inspection Standard Result Irritation Evaluation Suitability test for sensitive skin (primary irritation) GCP & MFDS‑approved protocol 0.00 No irritation (Excellent) Test Method: Test site wiped with 70% ethanol, product loaded in a Finn Chamber® and attached for 24 hours. Irritation assessed at 30 min & 24 hrs post‑removal. Test Location: Human Co., Ltd. Skin Clinical Trial Center, Korea. Participants: 33 adults with clinically confirmed sensitive skin. Clinically Measured Results at 3 Weeks Single‑arm evaluation (n=30). All changes significant vs. baseline (p<0.001). Deep Hydration (TDC) +14.19% Moisturemeter D Skin Brightness (L*) +0.78% Mark‑Vu Colorimeter Skin Texture (Ra, μm) −7.58% Antera 3D Dermis (Deep) Elasticity +2.46% Cutometer R2 • 8 mm Epidermal Elasticity +3.82% Cutometer R2 • 2 mm Skin Pores (Volume) −13.04% Antera 3D Methods: Moisturemeter D (TDC); Mark‑Vu Colorimeter (L*); Antera 3D (Ra, mean pore volume); Cutometer dual MPA 580 R2 (2 mm & 8 mm). Human Co., Ltd. Skin Clinical Trial Center (Korea). Three‑week application; results mean ± SD; all p<0.001 vs. baseline.
Learn more
How PLLACUBE Delivers Results with MTS, Laser & Topical Use
Discover how PLLACUBE adapts to microneedling, laser, and more. Clinically proven to improve hydration, elasticity, and pore appearance in just 3 weeks.
Learn more
What Is PLLACUBE? Meet the Science-Driven Cosmetic Skin Booster for Professional Use
Introduction – What Is PLLACUBE? PLLACUBE is an advanced all-in-one cosmetic skin booster developed for professional use in medspas, aesthetic clinics, and skin care studios. It features a science-backed formulation designed to support hydration, radiance, and skin conditioning — all while leveraging the patented INCUBE™ technology developed by Labincube Co., Ltd. in South Korea. Backed by Material Science: The INCUBE™ Innovation Founded in 2021, Labincube specializes in porous carrier materials and has developed a proprietary technology called INCUBE™ — based on Metal-Organic Frameworks (MOFs). This material helps stabilize active cosmetic ingredients and supports consistent formulation performance by controlling the release and integrity of ingredients such as Vitamin C and Glutathione. In other words, INCUBE™ acts as a delivery-support material that ensures cosmetic actives remain well-dispersed and stable until applied. PLLACUBE Skin Booster – Cosmetic Actives, Balanced Formulation There are two topical cosmetic products in the PLLACUBE lineup: PLLACUBE Original Poly-L-Lactic Acid (PLLA): Supports the appearance of skin elasticity and firmness PDRN (Sodium DNA): Conditions and hydrates skin for a revitalized appearance Vitamin C (Ethyl Ascorbyl Ether): Offers antioxidant support for a radiant-looking complexion Glutathione: Enhances skin brightness and overall glow Sodium Hyaluronate (HA): Helps maintain skin moisture Houttuynia Cordata Extract (Plant-based Exosome): Known for calming and conditioning effects PLLACUBE PiNk VoL. PLLA, PN (Polydeoxyribonucleotide), Vitamin C, Glutathione, and HA for similar cosmetic skin conditioning effects PLLACUBE Cosmetic Use & Professional Application Intended for professional use in cosmetic skin treatments Global Expansion & Industry Recognition PLLACUBE has been showcased at major industry events including: Cosmoprof Bologna (Italy) KIMES Seoul (International Medical Equipment Exhibition) These events spotlight innovation in cosmetic technology and skincare — and PLLACUBE has attracted attention for its ingredient integrity and cosmetic formulation science. Now Available in Canada Derma Essence Canada Ltd. is the official distributor of PLLACUBE products across Canada and North America. We are committed to providing professional-use, compliant cosmetic solutions backed by science, formulation stability, and visual performance. Interested in Offering PLLACUBE at Your Clinic? Contact us at info@derma-essence.com or explore our professional-use collection at www.derma-essence.com
Learn more