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PLLACUBE: How-to-Use / Protocol guide

Professional PLLACUBE cosmetic skinbooster used in clinic setting – Canada & USA

Lyophilized Form - The Gold Standard in Skinboosters


Unlike conventional skinboosters that come in pre-mixed liquid form, PLLACUBE is produced as a freeze-dried (lyophilized) shpere form— the most advanced — and most costly — form of ingredient preservation.



How to Activate PLLACUBE (Reconstitution Guide)

1. Prepare & Sanitize

  • Disinfect vial cap with alcohol swab
  • Wash hands and use sterile tools
  • Draw 2–5 cc sterile distilled water or saline





2. Add Diluent & Swirl

  • Slowly inject diluent along vial wall — avoid hitting the sphere directly
  • Gently swirl or roll the vial in your hands
  • Avoid vigorous shaking to protect sensitive actives





3. Allow Resting Time

  • Let the vial sit for ~2 minutes to allow PLLA and actives to hydrate fully
  • Do not disturb during this time — this improves even dispersion



4. Ready for Use

  • Gently swirl again to confirm full dispersion
  • Refrigerate if not using immediately; use within 48 hours after activation



Derma Essence Canada Ltd.
Why Reconstitution Time Matters

PLLA‑based skinboosters differ from typical HA boosters — they require complete dispersion before application.

  • PLLA is a biodegradable polymer that suspends rather than fully dissolves.
  • Many PLLA‑base products can take 20–30 minutes of mixing.

PLLACUBE’s Advantage

  • Freeze‑dried spherical form → faster, more uniform dispersion.
  • InCube™ Protection Technology → reduces clumping; preserves Glutathione, Vitamin C, PDRN.
  • ~4 minutes to reach a uniform suspension with gentle swirl + short rest; no aggressive shaking.

Clinic Tip: Confirm the solution is clear and evenly suspended before drawing. Refrigerate and use within 48 hours after activation.

Reference Guide
Treatment Modality Recommended Diluent Volume Consistency
Microneedling – Face 4 cc sterile distilled water or saline Light, even spread
Microneedling – Face & Neck 5 cc sterile distilled water or saline Slightly thinner
Post-Laser (LaseMD, C&B, etc.) 3.5 cc sterile distilled water or saline Balanced texture
JetPeel Infusion 5 cc sterile distilled water or saline Thinner, sprayable
While PLLACUBE is produced in a sterile, injectable-grade format to meet the highest sterile standards—and is used as an injectable in some countries—its intended purpose for the global market is for topical cosmetic use only.