PLLACUBE® TECHNOLOGY — OFFICIAL CANADA & U.S. DISTRIBUTOR
Give Your Clients Korea's Most
Advanced Skinbooster
PLLACUBE® is Korea's 5th-generation skinbooster — combining PLLA, PDRN, Vitamin C, Glutathione, and Hyaluronic Acid in one stabilized formula, powered by patented InCube™ Technology. Now available exclusively for registered clinics across North America.
PLLA · PDRN · Glutathione · Vitamin C · Plant-Derived Exosomes · Hyaluronic Acid
Developed by Lab InCube Co., Ltd. — Korean biomaterial R&D · Advanced Material Science · Applied Biotechnology
What is PLLACUBE?
Six Clinically Proven Actives.
One Stabilized System.
PLLACUBE® is a next-generation skinbooster combining Poly-L-Lactic Acid (PLLA), PDRN, Vitamin C, Glutathione, Houttuynia Cordata Extract, and Hyaluronic Acid — formulated to deliver both regenerative and brightening effects in a single professional-use vial.
Vitamin C and Glutathione — both highly susceptible to oxidation — are stabilized through the InCube™ Protection Platform developed by Lab InCube Co., Ltd.
Protected by international patent No. 10-2488551, InCube™ ensures maximum ingredient stability, controlled release, and consistent performance in every vial.
Learn More about LabInCube →Formulation Science
Key Ingredients of PLLACUBE® Original — All in One
Formulated with PLLA, PDRN, Vitamin C, Glutathione, Houttuynia Cordata Extract, and Hyaluronic Acid, PLLACUBE® Original offers a next-generation approach to professional skin revitalization. This synergistic combination is designed to help improve the appearance of firmness, clarity, and overall skin quality — supporting a smoother and more radiant complexion after treatment.
Among the actives, Vitamin C and Glutathione are safeguarded through the InCube™ stabilization platform, which helps maintain ingredient freshness and minimize oxidation during formulation, ensuring consistent quality in every vial.
InCube™ C·P·R Technology (Capsulation · Protection · Release) is a patented biomaterial stabilization system from Lab InCube Co., Ltd., ensuring superior stability and sustained ingredient performance.
Clinical Evidence
Clinical Results of PLLACUBE® Original
Clinically evaluated by the Human Skin Clinical Testing Center (2024), PLLACUBE® demonstrated significant improvements across multiple parameters including hydration, elasticity, skin tone, and texture refinement — confirming its performance for professional clinical use.
48.95%
Surface Skin Hydration
13.04%
Pore Refinement
3 Weeks
Observable Results
33
Study Participants
Study period: Jul. 23–Jul. 25, 2024 · Participants: 33 · Study No.: HM-P24-0335 · Testing Center: Human Skin Clinical Testing Center, Korea
For Licensed Clinics & Medspas
Ready to offer these results to your clients?
Wholesale pricing and full ordering access are available exclusively to registered clinic accounts. Apply and get approved within 1–2 business days.
Apply for Clinic AccessNo minimum order commitment · Health Canada registered · FDA cosmetic listed
Particle Engineering
Advanced PLLA Particle Technology
Precision-engineered PLLA particles are carefully designed into a spherical shape, promoting smooth application and even distribution. The uniform particle size of 30–80 µm enhances product consistency and performance, contributing to a refined, professional-grade skincare experience.
Micrograph images are illustrative to highlight particle morphology differences.
FAQ
1. What is PLLACUBE Original?
1. What is PLLACUBE Original?
PLLACUBE Original is a 5th-generation Korean skinbooster containing Poly-L-Lactic Acid (PLLA), PDRN, Vitamin C, Glutathione, Hyaluronic Acid, and Houttuynia Cordata extract. It is designed for topical use with microneedling to support skin rejuvenation, firmness, and radiance.
2. What makes PLLACUBE different from other skinboosters?
2. What makes PLLACUBE different from other skinboosters?
PLLACUBE is a multi-functional skinbooster that uniquely combines PLLA, PDRN, Glutathione, Vitamin C, Hyaluronic Acid, and plant extract into a single freeze-dried formula. It features InCube™ Technology, which helps protect fragile actives from oxidation and degradation — ensuring maximum potency upon reconstitution.
3. How is PLLACUBE used in clinical settings?
3. How is PLLACUBE used in clinical settings?
PLLACUBE is designed for professional use across a range of advanced skin rejuvenation protocols, including microneedling, RF microneedling, infusion-focused facial treatments like JetPeel™ or CureJet™, and post-laser care such as CO₂ fractional or thulium laser procedures. Once reconstituted, the solution may be applied topically or paired with appropriate delivery systems to optimize absorption. Usage volume and dilution may vary based on clinical technique and goals.
4. Why is PLLACUBE used as an injection in some countries?
4. Why is PLLACUBE used as an injection in some countries?
PLLACUBE was originally developed as a topical-use cosmetic skinbooster, specifically designed to pair with microneedling treatments. It is manufactured as an injection-grade sterile product to meet the highest safety standards. In some countries, PLLACUBE is registered as a medical device, which allows its use via injection. However, in the North American market (Canada and the U.S.), PLLACUBE is officially classified and registered as a cosmetic product for topical application only.
5. Is PLLACUBE Health Canada/FDA approved?
5. Is PLLACUBE Health Canada/FDA approved?
Yes. PLLACUBE is registered with Health Canada as a cosmetic product for topical use. it is officially listed with the U.S. FDA as a cosmetic product under the FDA’s Cosmetic Product Listing Program (CPLP).
6. Can PLLACUBE be combined with other skinbooster?
6. Can PLLACUBE be combined with other skinbooster?
It is best applied as a standalone booster step due to its multi-ingredient formula.
7. Does PLLACUBE require refrigeration or special storage?
7. Does PLLACUBE require refrigeration or special storage?
No refrigeration is needed. PLLACUBE is freeze-dried for stability and should be stored in a cool, dry place away from direct sunlight. Reconstitute with distilled water or saline only when ready to use.
8. Is PLLACUBE safe for all skin types?
8. Is PLLACUBE safe for all skin types?
PLLACUBE is dermatologist-tested and shown to be non-irritating in clinical trials. It is suitable for most skin types, including normal to mildly sensitive skin. As with all professional-use products, a clinical evaluation is recommended before use.
Professional Treatment Protocol
Access our comprehensive guide for using PLLACUBE with microneedling, RF treatments, and post-laser care protocols.
View Protocol GuideScientific Foundation
The Research Behind the Results
PLLACUBE's InCube™ Technology is not just patented — it's grounded in Nobel Prize-recognized molecular science, with peer-reviewed publications in leading international journals and co-authored research with Seoul National University Hospital.
2025 Nobel Prize in Chemistry
InCube™ is built on MOF science awarded the Nobel Prize. LabInCube's founder trained under Prof. Omar Yaghi at UC Berkeley — the Nobel laureate who pioneered MOF research.
Seoul National University Hospital
LabInCube co-authored peer-reviewed skin research with SNUH Bundang — Korea's most prestigious academic medical center — validating MOF technology in skin applications.
GCP-Certified Clinical Study
3-week study at Human Co., Ltd. Skin Clinical Trial Center, Korea. Statistically significant improvements across 5 skin parameters (p<0.001 vs. baseline).
5 Registered Patents
Protected by 5 Korean IP Office patents including Patent No. 10-2488551. Multi-porous encapsulation engineered for ingredient stability and controlled release.
Advanced Healthcare Materials · Wiley · 2023
Zirconium-Based MOF Capable of Binding Proinflammatory Mediators Promotes Wound Healing Through a Multiscale Adsorption Mechanism
In Vivo · 2024
Effect of Silicone Patch Containing Metal-Organic Framework on Hypertrophic Scar Suppression