Q: 6. Why is PLLACUBE used as an injection in some countries?

PLLACUBE was originally developed as a topical-use cosmetic skinbooster, specifically designed to pair with microneedling treatments. It is manufactured as an injection-grade sterile product to meet the highest safety standards. In some countries, PLLACUBE is registered as a medical device, which allows its use via injection. However, in the North American market (Canada and the U.S.), PLLACUBE is officially classified and registered as a cosmetic product for topical application only. it is intended strictly for topical professional use, often in conjunction with microneedling, RF microneedling, Infusion-focused medi-facials (e.g. JetPeel, Curejet, etc.), or post-laser-procedures.

Question 1

1. What is PLLACUBE Original?

Accepted Answer

PLLACUBE Original is a 5th-generation Korean skinbooster containing Poly-L-Lactic Acid (PLLA), PDRN, Vitamin C, Glutathione, Hyaluronic Acid, and Houttuynia Cordata extract. It is designed for topical use with microneedling to support skin rejuvenation, firmness, and radiance.

Question 2

2. What makes PLLACUBE different from other skinboosters?

Accepted Answer

PLLACUBE is a multi-functional skinbooster that uniquely combines PLLA, PDRN, Glutathione, Vitamin C, Hyaluronic Acid, and plant-derived exosomes into a single freeze-dried formula. It features InCube™ Technology, which helps protect fragile actives from oxidation and degradation — ensuring maximum potency upon reconstitution.

Question 3

3. How is PLLACUBE used in clinical settings?

Accepted Answer

PLLACUBE is designed for professional use across a range of advanced skin rejuvenation protocols, including microneedling, RF microneedling, infusion-focused treatments like JetPeel™ or CureJet™, and post-laser care such as CO₂ fractional or thulium laser procedures. Once reconstituted, the solution may be applied topically or paired with appropriate delivery systems to optimize absorption. Usage volume and dilution may vary based on clinical technique and goals.

Question 4

4. Who is PLLACUBE suitable for?

Accepted Answer

PLLACUBE is intended for professional topical application in clinical or medical aesthetic settings. It is suitable for clients seeking: • Skin hydration and radiance • Improved elasticity and firmness • Refined pore appearance • Post-laser recovery support  While results may vary, PLLACUBE is ideal for individuals undergoing cosmetic procedures like microneedling, RF-based therapies, or non-ablative laser treatments. For professional use only. Not intended for self-application.

Question 5

5. What is INCUBE™ Technology?

Accepted Answer

INCUBE™ is a patented technology (Patent No. 10-2488551) that protects active ingredients from degradation through selective encapsulation and timed release, enhancing overall efficacy and stability of the formula.This platform minimizes oxidation and degradation, allowing actives like Vitamin C and Glutathione to remain stable until reconstitution. InCube™ ensures enhanced ingredient performance during topical application.

Question 6

6. Why is PLLACUBE used as an injection in some countries?

Accepted Answer

PLLA­CUBE was originally developed as a topical-use cosmetic skinbooster, specifically designed to pair with microneedling treatments. It is manufactured as an injection-grade sterile product to meet the highest safety standards. In some countries, PLLACUBE is registered as a medical device, which allows its use via injection.  However, in the North American market (Canada and the U.S.), PLLACUBE is officially classified and registered as a cosmetic product for topical application only.  it is intended strictly for topical professional use, often in conjunction with microneedling, RF microneedling, Infusion-focused medi-facials (e.g. JetPeel, Curejet, etc.), or post-laser-procedures.

Question 7

7.  Is PLLACUBE Health Canada approved?

Accepted Answer

Yes. PLLACUBE is registered with Health Canada as a cosmetic product for topical use

Question 8

8. Can PLLACUBE be combined with other skinbooster?

Accepted Answer

It is best applied as a standalone booster step due to its multi-ingredient formula.

Question 9

9. Does PLLACUBE require refrigeration or special storage?

Accepted Answer

No refrigeration is needed. PLLACUBE is freeze-dried for stability and should be stored in a cool, dry place away from direct sunlight. Reconstitute with distilled water or saline only when ready to use.

Question 10

10. Is PLLACUBE safe for all skin types?

Accepted Answer

PLLACUBE is dermatologist-tested and shown to be non-irritating in clinical trials. It is suitable for most skin types, including normal to mildly sensitive skin. As with all professional-use products, a clinical evaluation is recommended before use

48.95%	Improvement in surface skin hydration after 3 weeks
13.04%	Pore refinement observed after 3 weeks
33	Participants · GCP-certified clinical study, Korea (2024)

PLLA (Poly-L-Lactic Acid)	Stimulates collagen production to restore firmness and elasticity over time
PDRN (Sodium DNA)	Accelerates cell regeneration and supports a revitalized complexion
Sodium Hyaluronate (HA)	Deep hydration for a plumper, more supple skin appearance
Vitamin C (Ethyl Ascorbyl Ether)	Antioxidant support — stabilized by INCUBE™ for full potency at point of use
Glutathione	Brightens skin tone and combats oxidative stress — stabilized by INCUBE™
Houttuynia Cordata Extract	Soothing and conditioning — supports skin recovery post-treatment

Product type	Cosmetic topical — for professional use only
Contents per carton	10 treatment vials (100mg each, 20mg PLLA)
Preparation	Add 3–5 mL isotonic solution or distilled water before use
Storage	Cool, dry place. No refrigeration required.
Origin	Made in Korea · Shipped from Canada
Regulatory	Health Canada registered · FDA Cosmetic Listed

48.95%	Improvement in surface skin hydration after 3 weeks
13.04%	Pore refinement observed after 3 weeks
33	Participants · GCP-certified clinical study, Korea (2024)

PLLA (Poly-L-Lactic Acid)	Stimulates collagen production to restore firmness and elasticity over time
PDRN (Sodium DNA)	Accelerates cell regeneration and supports a revitalized complexion
Sodium Hyaluronate (HA)	Deep hydration for a plumper, more supple skin appearance
Vitamin C (Ethyl Ascorbyl Ether)	Antioxidant support — stabilized by INCUBE™ for full potency at point of use
Glutathione	Brightens skin tone and combats oxidative stress — stabilized by INCUBE™
Houttuynia Cordata Extract	Soothing and conditioning — supports skin recovery post-treatment

Pllacube Original